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S-isomer ketamine is an enantiomer of the drug ketamine. It is a racemic mixture of the (S)- and (R)- enantiomers. S-isomer ketamine is less sedating than the R-isomer and is thought to have greater antidepressant properties. It is approved for use as an antidepressant in some countries, and clinical trials are underway in the US. S-isomer ketamine is also being investigated for the treatment of pain. It is also being studied for its potential to treat post-traumatic stress disorder, obsessive-compulsive disorder, and bipolar disorder. Research is ongoing to understand the exact mechanisms of how this drug ketamine works.

Studies have found that S-isomer ketamine acts on glutamate receptors in the brain, which helps to regulate mood and pain. It is believed that the drug may increase the amount of glutamate released in the brain, resulting in an antidepressant effect. Furthermore, animal studies have shown that S-isomer ketamine has anti-inflammatory properties, which could help to reduce pain. These findings suggest that S-isomer ketamine could be an effective treatment for depression and pain. Further research is needed to understand the long-term effects of the drug and to determine the best dosage for optimal therapeutic benefits. It is a promising treatment for depression and pain, but further research is needed before it can be used clinically. Clinical trials should also ensure the safety and efficacy of the drug before it is approved for use.

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