Methallylescaline Fumarate: Chemical Profile, Research Overview & Safety Information

What Is Methallylescaline Fumarate?

Methallylescaline Fumarate is a salt form associated with methallylescaline, a synthetic phenethylamine related structurally to mescaline. Researchers commonly discuss methallylescaline within the broader group of scaline and 3C-scalline compounds, which have been investigated for their interactions with serotonin receptors.

Methallylescaline itself is also known by chemical names such as 4-methallyloxy-3,5-dimethoxyphenethylamine. PubChem lists the parent compound with the molecular formula C14H21NO3 and a molecular weight of approximately 251.32 g/mol.

Because the fumarate form represents a salt rather than the free parent compound, its physical and analytical properties can differ from those of methallylescaline itself. Therefore, researchers should identify the exact chemical form when interpreting analytical data.

Methallylescaline Chemical Structure

Methallylescaline belongs to a family of substituted phenethylamines. Its structure contains a phenethylamine backbone together with methoxy and methallyloxy substituents.

Key Chemical Information

• Common name: Methallylescaline
• Chemical class: Substituted phenethylamine
• Related family: Scalines and 3C-scalines
• Parent molecular formula: C14H21NO3
• Parent molecular weight: 251.32 g/mol
• CAS Registry Number: 207740-41-8
• IUPAC name: 2-[3,5-dimethoxy-4-(2-methylprop-2-enoxy)phenyl]ethanamine
• PubChem CID: 44350127

These identifiers can help laboratories distinguish methallylescaline from chemically related substances.

Methallylescaline Fumarate Research

Scientists have studied methallylescaline as part of research into new psychoactive substances and substituted phenethylamines. However, the available evidence remains limited compared with established pharmaceutical compounds.

A recent metabolism study examined methallylescaline using computational prediction, zebrafish models, and human liver microsomes. The researchers specifically noted that limited toxicity information has made it difficult to fully understand the compound’s toxicological profile.

Therefore, researchers should avoid treating preliminary laboratory findings as evidence of established medical benefits.

Receptor Research

Research involving related scaline compounds has investigated several monoamine targets, including 5-HT1A, 5-HT2A, 5-HT2C, α1A, α2A, and D2 receptors.

One in-vitro study found that scalines and related 3C-scalines interact with serotonin receptors, particularly the 5-HT2A receptor, although the strength and selectivity of these interactions vary between compounds.

Importantly, receptor activity observed in laboratory experiments does not establish therapeutic effectiveness or clinical safety in humans.

Potential Research Applications

Methallylescaline may be relevant to laboratory research involving:

Analytical Chemistry

Researchers can investigate its molecular structure, identification, purity, and analytical characteristics using appropriate laboratory techniques.

Metabolism Research

Scientists have examined how methallylescaline may be metabolized using in-vitro, in-vivo, and computational approaches. Such research can help identify metabolites and improve toxicological understanding.

Pharmacology Research

Researchers have also examined related phenethylamines to better understand interactions with serotonin and other monoamine receptors. This work can contribute to broader research into psychedelic pharmacology.

Safety and Legal Considerations

Methallylescaline is a psychoactive research chemical, and its safety profile has not been established to the same standard as approved medicines. Available scientific literature also indicates that important toxicological information remains limited.

For that reason, researchers should not assume that experimental findings demonstrate human safety. In addition, legal controls can vary substantially between countries and jurisdictions. PubChem records methallylescaline in regulatory and drug-information databases, including a DEA classification record.

Anyone handling research chemicals should follow applicable institutional safety procedures, laboratory controls, and local laws.

Methallylescaline Fumarate: Important Takeaways

Methallylescaline is a synthetic substituted phenethylamine related to mescaline and the wider scaline family. Researchers have investigated its chemical properties, metabolism, and receptor interactions, but human clinical evidence remains limited.

Consequently, Methallylescaline Fumarate should be discussed primarily in the context of scientific research and analytical chemistry rather than established medical treatment. Reliable identification, appropriate laboratory controls, and careful interpretation of the available evidence are essential.