NDTDI (Ergoline): Research Chemical Summary, Structure, Properties and Safety

NDTDI is a synthetic ergoline and partial lysergamide compound. Researchers also know it as 9-desmethine-LSD, 9-nor-LSD or 8,10-seco-LSD. Structurally, NDTDI is a simplified analogue of LSD with some modification of the traditional ergoline framework. This relationship has made NDTDI a compound of interest in chemical and pharmacological studies.

However, there is no approved therapeutic indication for NDTDI. Its pharmacology is not yet fully characterised and therefore it should not be marketed as an approved medicine or dietary supplement.

What Is NDTDI?

NDTDI is a partial or simplified lysergamide, being a tricyclic compound structurally related to LSD. It is chemically known as N,N-diethyl-3-(methyl(1,3,4,5-tetrahydrobenzo[cd]indol-4-yl)amino)propanamide. The molecular formula of the compound is C19H27N3O and the molar mass is 313.45 g/mol.

NDTDI, compared to classic LSD, lacks the carbon atom at the 9 position of the ergoline ring system. Scientists therefore classify it as a simplified or partial lysergamide, and not as identical to LSD.

NDTDI and the Ergoline Family

Structural relation

The ergoline skeleton is an important structural element of many natural and synthetic compounds. Due to its simplified lysergamide structure, NDTDI is attributed to this family.

Other partial lysergamides and simple ergoline derivatives are listed with NDTDI in references. This structural relationship is of interest to those who study the effect of changes in chemical structures on biological activity.

NDTDI Other Names

You may find NDTDI in scientific and forensic literature under the following names:

• 9-desmethyl-LSD
• 9-nor-LSD
• 8,10-seco-lysergic acid diethylamide
• N,N-diethyl-3-[methyl(1,3,4,5-tetrahydrobenzo[cd]indol-4-yl)amino]propanamide

These names are synonyms of the same chemical and can help researchers locate analytical data.

NDTDI Chemical Properties

The molecular formula is C19H27N3O. Its reported structure features nitrogen and oxygen atoms inside a complex tricyclic framework. The molecular weight of the compound is approximately 313.45 g/mol.

Moreover, chemical databases provide a canonical structure representation and InChI information that can be used by researchers for identification and analytical purposes. These identifiers can be of particular use in situations where laboratories are differentiating NDTDI from structurally related compounds.

Research Interest of NDTDI

In 2016 NDTDI was recognised as a new designer compound by the researchers and in the following period it was identified for forensic purposes. Its structural analogy to LSD aroused interest in analytical chemistry and psychoactive substances.

But scientists will need to separate structural similarity from proven medical efficacy. There is no current information that would indicate that NDTDI is a treatment for any disease or medical condition.

Pharmacological Data and Effects

References characterise NDTDI as a psychedelic-related compound and report LSD-like activity in limited contexts. But its pharmacology has not been well studied, so scientists cannot reliably determine the full range of its effects, long-term risks, interactions, or therapeutic potential.

For this reason, this compound cannot be considered as an approved pharmaceutical product. Specifically, there is no recognised medical dose or clinically validated treatment protocol that can be recommended on the basis of the available evidence.

Safety and Legal Issues

NDTDI still has safety concerns. According to a decision by a Latvian health authority, NDTDI may present serious risks to health and life and has no recognised or approved therapeutic use outside of scientific research. In 2017, Latvia subsequently restricted NDTDI.

Laws vary between countries and are constantly changing. Therefore, researchers and organisations are responsible for verifying the applicable local laws before handling or studying this compound.

FAQs

Is Ergoline NDTDI?

NDTDI is closely related to ergoline and is usually discussed in the partial or simplified lysergamide/ergoline context. However, it is better described as a partial lysergamide and a simplified analogue of LSD.

NDTDI is not a drug.

NDTDI has no accepted medical indication or therapeutic use as a drug. Its pharmacology has not been sufficiently studied.

Is NDTDI the same thing as LSD?

None. NDTDI is an analogue of LSD, but it is a modified and simplified analogue that is structurally related to LSD. Chemically , it is not to be confused with LSD .

Why NDTDI?

The NDTDI is of interest to the researchers in terms of its chemical structure, its analytical identification, and the connection of simplified lysergamide structures to biological activity.

Summary

NDTDI is a research chemical from the partially lysergamide and ergoline family. It is also known as 9-desmethine-LSD, 9-nor-LSD and 8,10-seco-LSD. Its structure has been the focus of scientific and forensic interest, but researchers have not developed a complete pharmacological profile or an approved therapeutic use.

Therefore, accurate information should be given on the chemical identity, structural relationship, research history, analytical characteristics and safety considerations of a substance and not as a typical pharmaceutical.