3-HO-PCE: Chemical Data, Research Applications, Effects, Safety

What Is 3-HO-PCE?

3-HO-PCE, also known as 3-Hydroxyeticyclidine, or 3-Hydroxy-PCE, is a synthetic arylcyclohexylamine compound. It is generally classified as a dissociative new psychoactive substance (NPS) by researchers. Structurally it is related to compounds such as PCE and other arylcyclohexylamines.

3-HO-PCE has no established therapeutic use, unlike approved medicines. It has been studied mainly as a member of the family of new dissociative compounds and their chemical properties. There is still little scientific data on its impact on humans, its long-term effects and its toxicity.

3-HO-PCE Chemical Profile

3-HO-PCE has a molecular formula of C14H21NO and a molecular weight of approximately 219.32 g/mol. Its systematic (IUPAC) name is 3-(1-ethylamino)cyclohexyl)phenol. Researchers distinguish it from related compounds by the presence of a hydroxy substitution on the phenyl ring and an ethylamino moiety.

The compound appeared in research-chemical markets in the 2010s. But just because it’s available in those markets doesn’t mean it’s been proven safe, approved by medical authorities or clinically useful.

Important Chemical Information

• Common name: 3-HO-PCE
• Other names: 3-Hydroxy-eticyclidine
• Chemical class Arylcyclohexylamines
• Psychoactive category: Dissociative
• Chemical Formula: C14H21NO
• Mol. Weight: 219.32 g/mol
• CAS Number : 2243815-20-3
• Systematic name 3-[1-(Ethylamino)cyclohexyl]phenol

### How Does 3-HO-PCE Work? 3-HO-PCE is a powerful psychedelic that works primarily by stimulating serotonin receptors in the brain, especially the 5-HT2A subtype. This activation leads to altered perception, mood changes, and hallucinations, which are typical effects of psychedelics. The compound also affects other neurotransmitter systems, contributing to its overall impact on consciousness and cognition.

3-HO-PCE is part of the NMDA receptor drug group, which plays a role in glutamate signalling in the CNS, based on the data available so far. NMDA receptors are involved in learning, memory, sensing the environment and communication between neurones.

NMDA receptor antagonism is thought to be responsible for the dissociative properties associated with this chemical class. Nevertheless, scientists still need more controlled research to establish the exact pharmacological profile of 3-HO-PCE.

In addition, possible interaction with other receptor systems has been studied since structurally related compounds may produce complex effects. 3-HO-PCE are not to be regarded as clinical effects.

Research on 3-HO-PCE Metabolism

A scientific study from 2023 on the metabolism of 3-HO-PCE in human liver microsomes and biological samples. This work helped researchers to identify metabolic pathways, and improved the ability to detect the compound and its metabolites in toxicological samples.

The present work is of great importance for forensic and analytical toxicology. But to study metabolism is not to say a substance is safe or fit for human consumption.

Why is research on metabolism important?

Metabolism is important for scientists to understand because it can help scientists:

• Metabolites identification in biological fluids.
• Enhance laboratory detection techniques.
• Support Toxicology in Forensics.
• See how the body breaks down new materials.
• Enhance interpretation of toxicological testing.

Toxicological and Safety

The safety profile of 3-HO-PC is not well-established. Researchers have specifically noted that there is a lack of experimental data on its pharmacology, toxicity and long term effects. Thus it must not be considered as a proven safe compound.

More recent toxicology studies have classified 3-HO-PC with PCP-type analogues having limited experimental safety data and possible abuse-related concerns. Computational toxicology models can offer useful alerts but cannot replace controlled human safety studies.

Is 3-HO-PCE a drug?

3-HO-PC has no known medical use. It is not an approved treatment for pain, anxiety, depression or any other medical condition.

Therefore, product descriptions should not represent 3-HO-PC as a therapeutic medicine or make unsupported health claims. At present its main scientific importance is in the fields of chemical, pharmacological, metabolic, forensic and toxicological research.

3-HO-PC Summary

To summarise, 3-HO-PCE is a synthetic arylcyclohexylamine and dissociative research chemical with a relatively limited scientific evidence base. Scientists have determined some key information on its molecular makeup and metabolism, but its full pharmacology and toxicity profile is still being studied.

Responsible scientific discussion should therefore be directed towards analytical identification, chemical characterisation, metabolism, receptor pharmacology and toxicology, and not towards unsubstantiated medical or recreational claims.

FAQs

What is 3-HO-PCE?

3-HO-PC is short for 3-Hydroxyeticyclidine, a synthetic arylcyclohexylamine compound.

3-HO-PC has the molecular formula C13H18O2N.

The molecular formula is C14H21NO and the molecular weight is approximately 219.32 g/mol.

Is 3-HO-PC legal as a medicine?

None. It has no approved therapeutic indication.

Is 3-HO-PCE studied in scientific?

Yes. It has been studied for its metabolism and chemical properties, but there are still major gaps in pharmacology and toxicity studies.

What are the side effects of 3-HO-PCE?

None. The current literature shows that the safety and the toxicity data are limited.