3-Hydroxyphenazepam: Chemical properties, pharmacology, uses and safety profile

3-Hydroxyphenazepam is a benzodiazepine-related compound with pharmacological activity and is an active metabolite of phenazepam and cinazepam. Researchers have studied the compound for its ability to interact with the GABA-A receptor system and to cause depressant effects on the central nervous system. Therefore, it is important to consider 3-hydroxyphenazepam as a subject of research and pharmacology, and not as an ordinary supplement.

### What is 3-Hydroxyphenazepam?

3-Hydroxyphenazepam is a hydroxylated benzodiazepine. It is also named 3-oxyfenazepam and has the CAS Registry Number 70030-11-4. Its molecular formula is given by PubChem as C₁₅H₁₀BrClN₂O₂ and its molecular weight is 365.61 g/mol. 7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one is its IUPAC name.

Also, scientific databases show that 3-hydroxyphenazepam is an active metabolite of phenazepam. It has also been identified as the active metabolite of the benzodiazepine prodrug cinazepam in research.

Chemical Properties of 3-Hydroxyphenazepam

The compound has some useful identifiers for laboratory and analytical purposes.

Important Chemical Information

• Chemical name: 3Hydroxyphenazepam
• Other names: 3-Hydroxyphenazepam
• CAS #: 70030-11-4
• PubChem CID: 125820
• Molecular formula: C15H10BrClN2O2
• Molecular weight : 365.61 g.mol-1
• IUPAC name 7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• InChIKey KRJKJUWAZOWXNV-UHFFFAOYSA-N
• Topological polar surface area: 61.7 Å2

These identifiers can help laboratories to distinguish 3-hydroxyphenazepam from other benzodiazepine compounds during analytical testing.

How 3-Hydroxyphenazepam Works?

3Hydroxyphenazepam affects the GABA-A receptor, benzodiazepine site. In pharmacologic studies, it has been described as a positive allosteric modulator of GABA-A receptor activity. Therefore, it might enhance inhibitory signalling in the central nervous system.

GABA is an important inhibitory neurotransmitter and compounds that modulate this receptor system can have effects on neurological activity. The exact effects, however, can vary with the compound, the exposure, the individual characteristics, and the presence of other substances.

Pharmacological Properties

The research literature indicates that 3-hydroxyphenazepam has a number of benzodiazepine-like pharmacological properties including sedative, hypnotic, anxiolytic and anticonvulsant activity. Compared with phenazepam, published literature describes decreased muscle-relaxant activity but retention of several other pharmacological effects.

Research and Analytics Purposes

3-Hydroxyphenazepam was studied in pharmacology, toxicology, metabolism and analytical chemistry.

For example, this compound can be detected and quantified by laboratories with advanced analytical techniques such as LC-MS/MS and GC-MS. 3-Hydroxyphenazepam has been identified in biological samples and its relation to phenazepam metabolism has been studied.

Scientists have also studied its activity on the receptor and its interaction with nerve-terminal GABA-A receptors. These studies provide insight to researchers in the effect of benzodiazepine related compounds on the nervous system.

Safety of 3-hydroxyphenazepam

3-Hydroxyphenazepam is not a general health product. The benzodiazepine-related compounds can produce strong central nervous system effects. The research on 3-hydroxyphenazepam does not establish any safe self-medication regimen.

In addition, scientific and toxicological literature has reported cases of impairment and depressant effects following exposure to illicit benzodiazepines. Therefore, unsupervised use can be very dangerous.

Important Safety Information:

Don’t treat yourself with 3-hydroxyphenazepam just because you read about a product on the Internet. Also do not assume that information on another benzodiazepine is applicable to this compound. In case of exposure or clinical use, professional medical or toxicological advice is recommended.

FAQs

What is 3Hydroxyphenazepam?

3Hydroxyphenazepam is a benzodiazepine-related compound with pharmacological activity and is an active metabolite of phenazepam and cinazepam.

CAS Registry Number: 3Hydroxyphenazepam

70030-11-4 CAS Registry Number It is also listed at PubChem under accession number PubChem CID 125820.

What is its molecular formula?

Molecular formula is C15H10BrClN2O2 and the molecular weight is 365.61 g/mol.

Is 3Hydroxyphenazepam a benzodiazepine?

Yes. It is listed in scientific databases and literature as a benzodiazepine-related compound, acting on the GABA-A receptor system.

Is 3Hydroxyphenazepam good for self-medication?

None. It should not be used as a regular supplement, or for self-medication. Its pharmacologic activity and possible effects on the central nervous system require appropriate professional supervision.

Summary

3Hydroxyphenazepam is a significant compound in the benzodiazepine pharmacology and analytical toxicology. It is an active metabolite of both phenazepam and cinazepam, and therefore is of particular interest in metabolism research. It is also helpful in scientific research due to its chemical identifiers, receptor activity and analytical detection properties.

However it is pharmacologically active and may have CNS-depressant effects. It should be handled by researchers and professionals with appropriate safety controls. The primary sources of information about this compound should be reliable scientific databases and peer-reviewed research.