5-MAPB: Effects, Risks & Research / Chemistry

5-MAPB is a synthetic compound belonging to the group of so-called novel psychoactive substances (NPS). It is classified as a benzofuran-related compound and an N-methyl derivative of 5-APB by researchers. Little scientific information is available on this substance and its chemistry, pharmacology and toxicological profile are still being investigated.

### What is 5-MAPB? 5-MAPB (1-(benzofuran-5-yl)-N-methylpropan-2-amine) is a psychedelic benzofuran derivative that is structurally related to compounds like 5-APB and 6-APB. It is known for its entactogenic and hallucinogenic properties and has been sold as a designer drug since around 2011.

Chemical structure of 5MAPB N-methyl-5-(2-aminopropyl)benzofuran ( 5MAPB ) is C 12 H 15 NO. Its CAS number is 1354631-77-8 and its PubChem compound ID is 102336592. The compound is structurally related to 5APB and possesses some structural features with amphetamine-type substances .

5-MAPB does not have an established therapeutic indication, unlike approved medicines. Therefore, it is usually discussed by researchers within the framework of pharmacology, toxicology and novel psychoactive substances.

Chemical Structure of 5-MAPB

The molecular framework of 5MAPB is composed of a benzofuran ring and an N-methylated aminopropyl side chain. This structure also relates it chemically to other substituted benzofurans.

Because of the structural similarity of these compounds 5-MAPB has been investigated along with 5-APB. But structural similarities don’t mean the compounds have the same effects or safety profiles.

5MAPB Effects On The Brain What Does

5MAPB has been shown in laboratory studies to affect monoamine neurotransmitter systems. Experimental research has particularly focused on its interaction with the dopamine transporter (DAT) and its effects on dopamine signalling. One study found some evidence that 5-MAPB may inhibit the re-uptake of dopamine, producing stimulant-like effects in laboratory models.

Researchers therefore describe 5-MAPB as having stimulant and entactogen-like properties. But lab tests can’t necessarily predict how a substance will behave in humans.

Effects and Possible Risks Reported

Psychoactive effects are associated with 5-MAPB in reports and scientific literature. But reliable clinical information is still lacking. Reported adverse effects have included increased heart rate, hyperthermia, agitation, sleep disturbance, pupil dilation, jaw clenching, sweating, and anxiety.

More importantly, there are published medical literature documenting cases of acute toxicity associated with 5MAPB. One report cited severe toxicity necessitating intensive medical treatment. Researchers accordingly stress that the substance is not a medically safe or proven product.

Why Do We Need More Research?

There is very little information about the long-term effects, human pharmacokinetics, toxicity thresholds, or the potential health implications of 5MAPB. A published toxicology report noted that there was a lack of reliable clinical information on its effects and human pharmacokinetics.

That means scientists need more controlled research to figure out how the compound interacts with the body and how its risks compare to other psychoactive substances.

Summary of 5MAPB Research

5-MAPB is a new benzofuran compound that has been investigated by researchers for its stimulant and entactogen-like pharmacology. Its chemical relationship to 5-APB and amphetamine-type compounds makes it relevant to toxicological research.

However, there is limited clinical evidence and documented toxicity, so researchers cannot establish a reliable safety profile. Information on 5-MAPB should therefore be considered as scientific and educational information and not medical advice or endorsement of recreational use.

5-MAPB: Facts

• Chemical Name: N-methyl-5-(2-aminopropyl)-2H-1-benzofuran
• CAS No. 1354631-77-8
• Molecular formula: C₁₂H₁₅NO
• Molecular weight: about 189.25 g/mol as a freebase
• Compound class: Benzofuran / new psychoactive substance
• Related Compounds: 5-APB
• Research fields: analytical chemistry pharmacology toxicology
• Safety status: Human safety data are still limited

Conclusion:

5-MAPB is an important example of a new psychoactive substance that needs careful scientific evaluation. Laboratory studies have documented stimulant-related activity by researchers, but the available evidence also suggests potential toxicity. So, further toxicological and pharmacological studies are needed for a full understanding of its risks and biological effects.