R-30490: Chemical Profile, Molecular Properties, Research Background and Safety Data

R30490 is a synthetic opioid related compound, also referred to as 4-Methoxymethylfentanyl. Researchers first studied this compound in investigations of the structure and activity of fentanyl-related molecules. At present, R30490 is of primarily chemical and pharmacological interest rather than as an approved human drug.

What’s R-30490?

R30490 is a fentanyl-related substance identified as N-[4-(Methoxymethyl)-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide. Its CAS Registry Number is 60618-49-7 and its PubChem identifier is CID 124716. It is also assigned the identifier 03DNV05OD4 by the FDA Global Substance Registration System.

R-30490 was initially synthesised by researchers during structure-activity relationship studies of fentanyl family compounds. Thus, the importance of its historical significance is that it contributed to understanding how structural modifications affect the activity of opioid receptors.

Chemical Data R-30490

The available databases provide several important chemical properties:

• Common name, R30490
• Other name(s) Methylfentanyl, 4-methoxy-
• CAS Number: 60618-49-7
• PubChem CID 124716
• FDA UNII: 03DNV05OD4
• Molecular formula: C24H32N2O2
• Molecular Weight: ~ 380.52 g/mol
• Stereochemistry: Achiral
• Stereocenters defined: 0
• Charge: 0

These identifiers thus help researchers differentiate R-30490 from other compounds with similar names or structures.

R-30490 and the Mu-Opioid Receptor

An important aspect of the R-30490 research is its interaction with the mu-opioid receptor. Database records have identified this receptor with an agonist (R30490). Historically, studies of fentanyl analogues have used compounds such as R30490 in the study of the relationship of molecular architecture to opioid receptor activity.

Opioid receptor activation can have profound effects on the central nervous system and researchers must take appropriate laboratory controls when handling compounds in this class. Opioid-related substances can be especially dangerous when exposure occurs outside the controlled conditions of research settings.

Historical Background Research

R30490 was originally synthesised by researchers at Janssen Pharmaceutica during research into fentanyl derivatives. The study allowed scientists to investigate how changes to the fentanyl structure impacted receptor selectivity and pharmacological activity.

R-30490, however, was never pursued as a medicine for humans. So it should not be advertized as an approved treatment or a standard pharmaceutical product.

Safety and Research Issues

R-30490 is a very potent opioid-related compound, in a class that is to be handled with special caution. Potent opioids may cause serious adverse effects on the central nervous system including fatal respiratory depression.

Thus, researchers should use proper institutional procedures, chemical documentation, risk assessments, and laboratory safety controls when working with chemicals in this category. Moreover, scientists need to verify identity and purity with appropriate analytical techniques, not just by the labels of the products.

Is R30490 Legal?

None. References available show that R-30490 has not been introduced for use in man. It is not to be called an approved prescription drug, pain killer or therapeutic treatment.

Summary

R30490 is a historically important fentanyl related research compound and is also known as 4-Methoxymethylfentanyl. Its chemical identifiers are published as CAS 60618-49-7, PubChem CID 124716, and molecular formula C24H32N2O2. It was of particular interest to researchers for studying opioid receptor activity and structure-activity relationship.

R-30490 is related to potent opioid activity and is not known to have any therapeutic use in humans. Correct identification, controlled research practices and appropriate safety procedures remain essential.